While Sirius is not specifically mentioned, the image of Homer Simpson's plug an play satellite radio looks strikingly similar to the Sirius Sportster.
Sam Simon, creator of the cartoon classic known as the Simpson's happens to be a Howard Stern fan, and even created a radio sitcom featuring the "better half" of Stern Show staffers. The title of the radio sitcom was "The Bitter Half".
Satellite radio has garnered a presence on several television shows and video games, but to this point, it seems to be the first time the digital medium has been included in a cartoon.
So, how long before we see Homer Simpson's presets on the Sirius web page?
Honestly the unit they used in the Simpsons looks like a generic verision of either Sirius's Sportster or the XM SKI-FI. Regardless of which it is supposed to be, it definitely a plus to see it in the episode.